In vitro lytic efficiency of Staphylococcus aureus bacteriophages in bacteria from bovine mastitis: a meta-analysis

ABSTRACT: Bacteriophages have been investigated as alternative to the treatment of bacterial infections, including bovine mastitis, in production animals. In this meta-analysis, we evaluated vitro efficiency phages Staphylococcus aureus against S. aureus, which is involved etiology mastitis. Seventeen studies were included and lytic activity was extracted using proportion analysis. The obtained meta-analysis a random-effects model [significant difference (P<0.05)]. Forest plots used graphically represent on isolates. Most (e.g., CS1, DW2, ΦSA011, ΦSA012, ΦSA022, ΦSA023, ΦSA024, ΦSA025, ΦSA037, ΦSA038, ΦSA039, ΦSA041, ΦSA042, ΦSA043, ΦSA044, MSA6, Ufv-aur2 Ufv-aur11, SAH-1, SPW, vB_SauM_JS25, SaPh1 SaPh6, SA, SANF, SA2, phi11, phiIPLA88, phiIPLA35, phiIPLA-RODI, phiIPLA-C1C, SAJK-IND, vBSP-A1, vBSP-A2, STA1.ST29, EB1.ST11, EB1.ST27, Remus, ISP) efficiently lytics or infected most isolates, demonstrating 80% (P<0.05) efficiency. SANF also demonstrated non-Staphylococcus Macrococcus caseolyticus compared host range phages. Additionally, an be researched treat mastitis dairy cattle caused by prevalent microorganism, aureus.